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KMID : 0357920140480050361
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Korean Journal of Pathology
2014 Volume.48 No. 5 p.361 ~ p.365
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Alveolar Soft Part Sarcoma of the Uterine Cervix: A Case Report and Review of the Literature
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Lee Hyun-Ju
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Abstract
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Alveolar soft part sarcoma (ASPS) of the uterine cervix is a rare malignancy, and 21 cases have been reported the literature from every language (including our case). Herein, we describe a 17-year old female patient who presented with active vaginal bleeding. Pelvic examination revealed a 1.6×1.0×0.5-cm-sized soft mass protruding from the uterine cervix. The final pathological diagnosis was ASPS of the uterine cervix. Immunohistochemically, tumor cells were strongly nuclear positive for transcription factor E3. The patient remained disease free for 24 months without adjuvant therapy. The prognosis of ASPS in the cervix is considerably better than that of ASPS in soft tissues due to early clinical detection, small size, and resectability. ASPS should be considered in the differential diagnosis of an unusual epithelioid neoplasm showing organoid appearance with mild cytologic atypia and no/rare mitotic figures, particularly in young women. Pathologists should be aware of those unusual locations where ASPS may originate.
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KEYWORD
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Sarcoma, alveolar soft part, Cervix uteri, TFE3, Immunohistochemistry
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